Twenty-five patients with long standing deep stromal herpetic keratitis and iritis were treated with acyclovir (3%) ointment and corticosteroids. All patients healed in about two to four weeks, independent of the duration of the keratitis before acyclovir treatment and independent of the antiviral m
Acyclovir treatment in stromal herpetic keratitis
β Scribed by J. A. Oosterhuis; R. Ganswijk; J. Versteeg
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 427 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0012-4486
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β¦ Synopsis
Thirty-five patients with long-standing deep stromal herpes simplex keratitis were treated with 3% acyclovir ointment and corticosteroids. All patients were cured in 2 to 4 weeks, independent of both the duration of the keratitis before acyclovir therapy and the previous antiviral medication. Corticosteroids in tapering dosages had to be continued for many months after healing to prevent recurrence of stromal corneal oedema; recurrences could not be prevented by acyclovir therapy. No serious side-effects of acyclovir were noted.
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The measurement of the local IgG response in ocular Herpes simplex virus infection presents particular problems due to the difficulty in obtaining sufficient tear samples and the possible transudation of IgG from the serum to the inflamed eye. Using specific monoclonal antibodies to Human IgG subcla