Acyclic imides. A general method of N-acylation of amides
โ Scribed by Baburao, K.; Costello, A. M.; Petterson, R. C.; Sander, G. E.
- Book ID
- 120980957
- Publisher
- The Royal Society of Chemistry
- Year
- 1968
- Tongue
- English
- Weight
- 361 KB
- Category
- Article
- ISSN
- 0022-4952
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The acyclic imides derived from primary benzylic amines and amino acid esters easily undergo the novel N~C acyl migration reaction via a base-generated carbanion, yielding the corresponding o~-aminoketones which are expedient precursors for 13-aminoalcohols.
Acyclic secondary amides such as benzanilides 1a-g, acetanilides 2a-d, and benzamide 1h undergo selfcondensation in the presence of phosphoric anhydride to produce, in one step, N-substituted aroyl benzamidines 3a-g, acyl acetamidines 4a-d, and imide 5, respectively. Mechanistic evidence is presente