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Acute target organ toxicity of 1-nitronaphthalene in the rat

✍ Scribed by Dale E. Johnson; Michael G. I. Riley; Herbert H. Cornish

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
533 KB
Volume
4
Category
Article
ISSN
0260-437X

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✦ Synopsis

1 -Nitronaphthalene (1 -NN) produced respiratory distress and centrilobular liver necrosis in male Sprague-Dawley rats after a single intraperitoneal injection (100 mg kg-'). Microscopic examination of the lungs of rats killed 24 h after the injection revealed a highly selective non-ciliated bronchiolar (Clara) cell necrosis as the only remarkable lesion. Pretreatment of animals with phenobarbital offered complete protection from the respiratory distress induced by 1-NN, but increased the severity of the hepatotoxicity. Pretreatment with SKF-525A protected against 1-"-induced liver necrosis, but did not alter the incidence or severity of the respiratory distress. Under similar conditions, this pattern of toxicity was not seen with the structural analogue 2-nitronaphthalene.

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