The effects of fasting on the acute oral toxicity of nine chemicals in the rat

✍ Scribed by O. L. Dashiell; Gerald L. Kennedy Jr

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 516 KB
• Volume: 4
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550040608

✦ Synopsis

Nine chemicals, with a range from extremely to slightly toxic, were used to measure the oral LDS0 in both fasted (24-h) and non-fasted rats. Each chemical was tested as a solution or suspension in corn oil, responses within 14 days post-treatment were evaluated, and LDsos were calculated. Hexachlorophene was more toxic in non-fasted rats. The LD5o values for tetraethyl lead, methomyl and hexamethylenediamine were essentially the same in both fasted and non-fasted rats. Adiponitrile, bromobenzene, caffeine, carbon tetrachloride and N-butyl-l,6-hexamediamine yielded lower LDso values in fasted rats. The use of nonfasted rats in acute oral toxicity determinations allows both the establishment of relative potency and the estimation of dosage levels for further repeated dose oral studies. The LDS0 values obtained were generally (7 of 9) higher in non-fasted rats, but the magnitude of the differences was not great enough to suggest routine use of both fasted and non-fasted rats in oral toxicity studies.

Chemicals tested and test conditions

The nine chemicals tested, supplied by E. I. du Pont de Nemours unless otherwise specified, were as follows: