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Acute sporadic hepatitis E in Kuwait

✍ Scribed by MD Abraham Koshy; Allen L. Richards; Siham Al-Mufti; Saroj Grover; Mohamed A. Shabrawy; Alexander Pacsa; Abdul-Aziz H. Al-Anezi; Basil Al-Nakib; Jim Burans; Mitchell Carl; Kenneth C. Hyams

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 474 KB
Volume: 42
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890420413

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fifty‐seven adult patients with acute hepatitis and 34 comparison patients without liver disease were evaluated using a newly developed Western blot assay for IgM antibody to hepatitis E virus. The mean age of patients with hepatitis was 32 years (range, 18‐55 years); 88% were male. Among patients with acute hepatitis, hepatitis A (anti‐HAV IgM positive) was diagnosed in two (4%), hepatitis B (anti‐HBc IgM positive) in three (5%), and hepatitis E (anti‐HEV IgM positive) in 34 (60%). One hepatitis patient had CMV IgM, another had EBV IgM, and 16 others (28%) were negative for all serologic markers of acute viral hepatitis. No patient with acute hepatitis A or B and none of the comparison patients without acute hepatitis had anti‐HEV IgM. All but one case of acute hepatitis E were found among expatriates of Asian origin, and acute hepatitis E was associated significantly with recent travel to the Indian subcontinent. These data suggest that acute hepatitis E is common among foreign workers in Kuwait but that little HEV transmission is occurring directly in Kuwait. © 1994 Wiley‐Liss, Inc.

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