✦ LIBER ✦

Acute promyelocytic leukemia: Cytogenetics and bone-marrow culture

✍ Scribed by Jan Fraser; P. E. Hollings; P. H. Fitzgerald; A. Day; Vivienne Clark; D. C. Heaton; J. W. Hamer; M. E. J. Beard

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 629 KB
Volume: 27
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910270207

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Six patients were diagnosed as having acute promyelocytic leukemia (APL) according to FAB criteria. One patient conformed to the M3 variant. Informative cytogenetic results (G‐banding) on five of the patients showed that three of them, including the M3 variant, had the 15;17 translocation in bone‐marrow or blood cells. Cells with the translocation were accompanied by cells with a normal karyotype in all patients and no other chromosomal abnormality was present. This first report of the 15;17 translocation from the South Pacific region is relevant to the uneven geographical distribution of APL patients with the translocation. Five of the six patients, including the M3 variant, showed a distinctive pattern of cell growth in agar culture characterized by a profusion of small, uniform clusters containing 6–20 cells with the appearance of promyelocytes. The remaining patient had a pattern of cell growth more typical of M2 acute leukemia. This cell growth pattern may be useful in diagnosing and monitoring the course of APL.

📜 SIMILAR VOLUMES

Bone marrow trephine biopsy findings in

Bone marrow trephine biopsy findings in acute promyelocytic leukemia

✍ Saeed Al-Shieban; Christine Liu; Keith Fishlock; Philippa C. May; Jiri Pavlu; Ki 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB 👁 2 views

A woman in her 20s presented with menorrhagia, bleeding gums, and frank hematurea. Her hemoglobulin was 9.2 g/ dL and white cell count was 3.1 3 10 9 /L, with neutrophils amounting to 0.6 3 10 9 /L. Her platelets measured 12 3 10 9 /L. She also had deranged clotting with prolonged prothrombin time,

Acute promyelocytic leukemia (APL) with

Acute promyelocytic leukemia (APL) with an unusual cytogenetic presentation

✍ Yorulmazoglu, Erol; Gezer, Sefer; Gregory, Stephanie A.; Hsu, Wei-Tong 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 29 KB 👁 2 views

We present a patient with APL because of the therapeutic implications of the singular chromosomal rearrangement present in his leukemic cells. Our patient is a 60-year-old male who presented with easy bruisability, gum bleeding, weakness, decreased appetite, and night sweats. He is a retired admiral

Quantitative acute leukemia cytogenetics

✍ Dr. Felix Mitelman; Sverre Heim 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 811 KB

Using literature data on cytogenetic abnormalities in 3,6 I 2 cases of acute myeloid leukemia (AML) and I ,55 I cases of acute lymphocytic leukemia (ALL), we have attempted to quantify the information value of finding the typical ALL-and AMLassociated chromosome aberrations. Sensitivity, specificity

Extramedullary acute promyelocytic leuke

Extramedullary acute promyelocytic leukemia

✍ Peter H. Wiernik; Roberto De Bellis; Pablo Muxi; Janice P. Dutcher 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 2 views

## BACKGROUND. Extramedullary acute promyelocytic leukemia (APL) is rare, and said to be more common after treatment with all-trans retinoic acid (ATRA) than after any other treatment. ## METHODS. The case of a child with extramedullary relapse of APL after initial treatment with ATRA and that

Extramedullary acute promyelocytic leuke

Extramedullary acute promyelocytic leukemia

✍ Frederic Maloisel; Jean Emmanuel Kurtz; Francis Oberling 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 47 KB 👁 2 views

Extramedullary acute promyelocytic leuke

Extramedullary acute promyelocytic leukemia

✍ Mustafa Benekli; M. Cemil Savaş; İbrahim C. Haznedaroǧlu 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 52 KB 👁 2 views

Because extramedullary depositions of APL are uncommon, information concerning the therapeutic Department of Orthopaedics University Ho ˆpital H. Mondor role of ATRA in extramedullary disease is insufficient. In their article, Wiernik et al. state that at least one Creteil, France Gaetano Bacci, M.D