The mycotoxin ochratoxin A (OTA) is a chlorinated dihydroisocoumarin derivative connected through an amide-bond to L-phenylalanine. In a previous study we could show that competition with Lphenylalanine-dependent processes does not play a role in OTA neurotoxicity. To test whether the isocoumarin pa
Acute neurotoxic effects of the fungal metabolite ochratoxin-A
✍ Scribed by V. Sava; O. Reunova; A. Velasquez; R. Harbison; J. Sánchez-Ramos
- Book ID
- 116779624
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 836 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0161-813X
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Aurovartin B, a metabolitt of Calcarianori which the absolute configuration could be unambiguously confirmedl2). Our synthetic process to (-)-aurovertin B (l), summarized in Scheme I and II, was started from the readily accessible branched-chain sugar (21'3). At the outset, the tertiary hydroxyl gro
Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium that is widely found as a contaminant of food products. The toxin is a renal carcinogen in male rats, the cause of mycotoxicoses in pigs and has been associated with chronic human kidney diseases. Bioactivation has been implic