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Acute myeloid leukemia (AML) with t(8;21)(q22;q22) relapsing as AML with t(3;21)(q26;q22)

✍ Scribed by Ulrike Bacher; Susanne Schnittger; Wolfgang Kern; Guido Trenn; Martin Weisser; Torsten Haferlach; Claudia Schoch


Book ID
113512918
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
95 KB
Volume
168
Category
Article
ISSN
0165-4608

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## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in ∼55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β€²__RUNX1__/3β€²__RUNX1T1__ fusion gene occurs in ∼8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a

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