Acute myeloid leukemia (AML) with t(8;21)(q22;q22) relapsing as AML with t(3;21)(q26;q22)
β Scribed by Ulrike Bacher; Susanne Schnittger; Wolfgang Kern; Guido Trenn; Martin Weisser; Torsten Haferlach; Claudia Schoch
- Book ID
- 113512918
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 95 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0165-4608
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## Abstract In acute myeloid leukemia (AML), nonrandom clonal chromosome aberrations are detectable in βΌ55% of adult cases. Translocation t(8;21)(q22;q22) resulting in the 5β²__RUNX1__/3β²__RUNX1T1__ fusion gene occurs in βΌ8% of AML cases. Also, ins(8;21) and ins(21;8) have been described that show a
A case of acute nonlymphocytic leukemia with homozygosity for the chromosome segment 8pter-4q22 is reported. A t(8;2 l)(q22;q22) translocation was associated with duplication of the derivative chromosome 8q-and absence of the normal chromosome 8. These rearrangements also yielded hemizygosity for 8q