Two adult patients with T cell acute lymphoblastic leukemia (ALL) received an intensive multiagent therapeutic regimen and failed to enter remission. Following cytoreduction with cyclophosphamide (60 mg/kg x 2) and total body irradiation (1000 rads) they underwent bone marrow transplantation. One pa
Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor
β Scribed by Lee Gong Lau; Lip Kun Tan; Evelyn S.C. Koay; Melvin H.L. Ee; Suat Hoon Tan; Te Chih Liu
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 228 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0361-8609
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TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL