✦ LIBER ✦

Acute lymphoblastic leukemia with myeloperoxidase activity

✍ Scribed by Wright, Susan; Chucrallah, Antoine; Chong, Yap Yee; Kantarjian, Hagop; Keating, Michael; Albitar, Maher

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 473 KB
Volume: 51
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199602)51:2<147::aid-ajh9>3.0.co;2-y

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✦ Synopsis

The French-American-British (FAB) classification of acute leukemias is based on the light microscopic detection of myeioperoxldase (MPO) activlty in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO-positive acute lymphobiastic leukemia

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