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Acute lymphoblastic leukemia with an unusual t(8;14)(q11.2;q32): a Pediatric Oncology Group study

✍ Scribed by Kaleem, Z; Shuster, J J; Carroll, A J; Borowitz, M J; Pullen, D J; Camitta, B M; Zutter, M M; Watson, M S


Book ID
110054457
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
83 KB
Volume
14
Category
Article
ISSN
0887-6924

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Cytogenetic analysis of a pediatric T-cell acute lymphoblastic leukemia (ALL) cell line (HPB-ALL) revealed the cryptic t(5;14)(q35;q32.2), recently found in 15-20% pediatric T-ALL patients, with 5q35 and 14q32.2 breakpoints at 5'-HOX11L2 and 3'-BCL11B, respectively. Expression of both BCL11B, which