Acute hepatic encephalopathy with diffuse cortical lesions
โ Scribed by S. M. Arnold; T. Els; J. Spreer; M. Schumacher
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 116 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0028-3940
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๐ SIMILAR VOLUMES
## Abstract Increased ammonia is a major pathogenic factor in hepatic encephalopathy (HE), a neurologic syndrome associated with glutamatergic dysfunction. Previous studies have shown that in rat cerebral cortical slices or a gliaโderived cell line, acute treatment with ammonia in vitro and in vivo
Functional changes of various neurotransmitter systems have been implicated in the pathogenesis of hepatic encephalopathy. In this study the role of brain monoaminergic neurotransmitter systems in hepatic encephalopathy was investigated in rats with thioacetamide-induced acute liver failure. Concent