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Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle

โœ Scribed by Yasutomo Sakai; Yukio Iwamura; Jun-Ichi Hayashi; Nao Yamamoto; Norio Ohkoshi; Hiroshi Nagata

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
588 KB
Volume
22
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

The present study was conducted to determine the effects of acute overload exercise on mitochondrial DNA and the structure of skeletal muscles. Rats were forced to run for 20 min until reaching complete exhaustion. We detected the large-scale deletion (7052 bp) of mitochondrial DNA by the nested polymerase chain reaction, and also observed mitochondrial ultrastructural changes in the soleus muscle.

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