The capacity of the specific narcotic antagonists naltrexone and naloxone to block the discriminative effects produced by morphine in the rat were evaluated using a two-choice, discrete-trial avoidance task. The antagonists produced a dose-dependent and time-dependent blockade of morphine's effects
Acute effects of naloxone and naltrexone, but lack of delayed effects, on exploratory behavior in the rat
โ Scribed by W. Koek; J. L. Slangen
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 611 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration o
The effects of morphine (10 mg/kg), nalorphine (1 and 10 mg/kg), and naloxone (1 mg/kg) were studied on the neoeortical release of aeetylcholine (ACh) in midpontine pretrigeminal transected rats. Morphine and, to a lesser extent, nalorphine decreased ACh release. Naloxone was ineffective alone but a