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Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells

✍ Scribed by Lydie Sparfel; Maud Loewert; Laurence Huc; Léa Payen; André Guillouzo; Dominique Lagadic-Gossmann; Olivier Fardel

Book ID
119537260
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
168 KB
Volume
129
Category
Article
ISSN
0378-4274

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The carcinogen 2-acetylaminofluorene inh
The carcinogen 2-acetylaminofluorene inhibits activation and nuclear accumulation of cyclin-dependent kinase 2 in growth-induced rat liver
✍ Birgitte Lindeman; Ellen Skarpen; Morten P. Oksvold; Henrik S. Huitfeldt 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB

Growth arrest in G 1 is a common cellular response to DNA damage. In the present study, liver regeneration was combined with continuous exposure for 2-acetylaminofluorene (AAF) to study mechanisms of carcinogen-induced growth arrest in vivo. Growth arrest of uninitiated hepatocytes is central for AA