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Acute and long-term proteome changes induced by oxidative stress in the developing brain

โœ Scribed by Kaindl, A M; Sifringer, M; Zabel, C; Nebrich, G; Wacker, M A; Felderhoff-Mueser, U; Endesfelder, S; von der Hagen, M; Stefovska, V; Klose, J


Book ID
110017098
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
419 KB
Volume
13
Category
Article
ISSN
1350-9047

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## Abstract Dichoroacetate (DCA) and trichloroacetate (TCA) were found to be hepatotoxic and hepatocarcinogenic in rodents. To investigate the role of oxidative stress in the longโ€term hepatotoxicity of the compounds, groups of mice were administered 7.7, 77, 154 and 410โ€‰mgโ€‰kg^โˆ’1^ per day, of eithe