𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Activity of renal 25-hydroxyvitamin D3-1α-hydroxylase in a case of X-linked hypophosphataemic rickets

✍ Scribed by Y. Seino; K. Satomura; K. Yamaoka; Y. Tanaka; H. Tanaka; T. Yamamoto; M. Ishida; H. Yabuuchi

Publisher
Springer
Year
1984
Tongue
English
Weight
435 KB
Volume
142
Category
Article
ISSN
0340-6997

No coin nor oath required. For personal study only.

✦ Synopsis

In 1974, a 2-year-old boy was diagnosed as having X-linked hypophosphataemic rickets (XLH) because of severe rickets and hypophosphataemia. The vitamin D metabolite concentrations, blood and urine chemistry and renal 25-hydroxyvitamin D3 (25OHD3)-1 alpha-hydroxylase were measured in 1982 (about 2 weeks after withdrawal of medication). 1 alpha-hydroxylase was 392 pg/mg tissue/20 min in the patient, which was high compared with aged-matched controls (69.7 +/- 28.5 pg/mg tissue/20 min, mean +/- SD, n = 7). Our present studies showed that the 1 alpha-hydroxylase activity in the patient with XLH was elevated. Therefore, the normal or low 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) concentrations in XLH patients could be due to accelerated catabolism of 1,25-(OH)2D3 or abnormally regulated 25OHD3-1 alpha-hydroxylase in response to hypophosphataemia, although significantly elevated above that in normal controls.

📜 SIMILAR VOLUMES

Measurement of 25-hydroxyvitamin D-1α-hy
Measurement of 25-hydroxyvitamin D-1α-hydroxylase activity in mammalian kidney
✍ Bruce Lobaugh; Marc K. Drezner 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 594 KB

Until recently measurement of 25-0H-D r Ia-hydroxylase activity in mammalian kidney has not been possible due to the presence of a protein which inhibits the enzyme by reducing available substrate. However, utilization of sufficient unlabeled 25-0H-D 3 (80 nmol/ml renal homogenate) to overcome the e

Differentiating and antitumor activities
Differentiating and antitumor activities of 1α,25-dihydroxyvitamin D3 in vitro and 1α-hydroxyvitamin D3 in vivo on human osteosarcoma
✍ Dr. Hiroyuki Tsuchiya; Hajime Morishita; Katsuro Tomita; Yoshimichi Ueda; Motohi 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 813 KB

## Abstract The differentiating and antitumor activities of 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) in vitro and 1α‐hydroxyvitamin D~3~ (1α(OH)D~3~) in vivo were studied with a human osteosarcoma cell line (OST strain). Antitumor activity was estimated with the use of 3‐(4,5‐dimethylthiazol)

Inhibition of angiogenesis as a mechanis
Inhibition of angiogenesis as a mechanism for inhibition by Lα-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by azoxymethane in Wistar rats
✍ Kazushige Iseki; Masaharu Tatsuta; Hiroyuki Uehara; Hiroyasu Iishi; Hiroyuki Yan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 57 KB 👁 1 views

The effects of 1␣-hydroxyvitamin D 3 [1␣(OH)D 3 ] and 1,25dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] on the incidence of colon tumors induced by azoxymethane and on the labeling index and angiogenesis of colon tumors were investigated in Wistar rats. Rats received 10 weekly injections of 7.4 mg/kg body

The vitamin D receptor-mediated activati
The vitamin D receptor-mediated activation of phosphatidylinositol 3-kinase (PI3Kα) plays a role in the 1α,25-dihydroxyvitamin D3-stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines
✍ Philip J. Hughes; Jimmy S. Lee; Neil E. Reiner; Geoffrey Brown 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB

## Abstract In this article we show that 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) stimulates the activity of the class IA phosphatidylinositol 3‐kinase PI3Kα and its downstream target Akt in HL60, U937 and THP‐1 myeloid leukaemic cell lines. Furthermore, we show that the classical nuclear vit

The active ester N-fmoc-3-O-[Ac4-α-D-Man
The active ester N-fmoc-3-O-[Ac4-α-D-Manp-(1→2)-Ac3-α-D-Manp-1-]=thre-O-Pfp as a building block in solid-phase synthesis of an o-linked dimannosyl glycopeptide.
✍ Anita Ma. Jansson; Morten Meldal; Klaus Back 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 276 KB

The active ester ilP-Rnoc-3-o\_IAc~~-o-Manp-(l~2)-Ac~ar-D-Manpl-J-~r-O-Pfp (6) was synthesized by direct condensation of Aqor-D-Mmp-(l-2)-Ac=ar-D-h&p-Br (4) with l+noc-Thr-0-m (5) and used as a buikiing block in an automated continwus-flow solid-phase synthesis of an 0-glycosylated heptadeca amino a