✦ LIBER ✦
The active ester N-fmoc-3-O-[Ac4-α-D-Manp-(1→2)-Ac3-α-D-Manp-1-]=thre-O-Pfp as a building block in solid-phase synthesis of an o-linked dimannosyl glycopeptide.
✍ Scribed by Anita Ma. Jansson; Morten Meldal; Klaus Back
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 276 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The active ester ilP-Rnoc-3-o_IAc~~-o-Manp-(l~2)-Ac~ar-D-Manpl-J-~r-O-Pfp (6) was synthesized by direct condensation of Aqor-D-Mmp-(l-2)-Ac=ar-D-h&p-Br (4) with l+noc-Thr-0-m (5) and used as a buikiing block in an automated continwus-flow solid-phase synthesis of an 0-glycosylated heptadeca amino acid fragment of the insulin-like growth factor I (IGF-I).