Free radicals have been implicated in the pathogenesis of an increasing number of disease and inflammatory states. They may cause cell and tissue damage by chemical modification of proteins, carbohydrates, nucleotides and lipids. Under physiological conditions free radicals are parts of normal regul
Activity of Nitric Oxide Synthase and Concentration of Nitric Oxide End Metabolites in the Gingiva under Experimental Pathological Conditions
β Scribed by V. L. Popkov; I. A. Fil'chukova; N. V. Lapina; V. P. Galenko-Yaroshevskii; A. S. Dukhanin
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 297 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0007-4888
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Nitric oxide synthase (NOS) activity was measured in extensor digitorum longus (EDL) and soleus muscles during postnatal development in the rat. At 1 and 2 weeks of age, similar low levels were found in both muscles. After 2 weeks, activity increased significantly only in EDL. Adult NOS activity was
## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a doseβdependent increase of NO g