Activity of a new nitrosourea (TCNU) in human lung cancer xenografts
β Scribed by Fergusson, RJ; Anderson, LE; Macpherson, JS; Robins, P; Smyth, JF
- Book ID
- 109836088
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 730 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0007-0920
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π SIMILAR VOLUMES
The cytotoxic activity of a new nitrosourea, TCNU, was compared with that of BCNU in five human small cell lung cancer cell lines in vitro. TCNU was found to be equivalent or inferior to BCNU when compared on a microgram to microgram basis. If the potential of in vitro phase II trials for selection
The development of nitrosoureas has switched from more lipophilic derivatives to congeners with higher water-solubility, since this property was presumably associated with a decrease in myelosuppression. We have compared the therapeutic efficacy of clinically well-known lipophilic nitrosoureas BCNU,