Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications
β Scribed by Guhan Nagappan; Bai Lu
- Book ID
- 116917897
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 635 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0166-2236
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Activity-dependent changes in synaptic strength, which appear to underlie cortical plasticity, require long-lasting biochemical changes in the postsynaptic neuron. An inductive event common to several forms of synaptic plasticity is an influx of calcium into the postsynaptic cell. Calcium acts as a
## Abstract The present work tested the hypothesis that the anatomic and developmental patterns of status epilepticusβinduced increases of brainβderived neurotrophic factor (BDNF) protein coincided with status epilepticusβinduced increases of phosphoβTrk immunoreactivity, a measure of TrkB receptor