✦ LIBER ✦

Molecular mechanisms underlying activity-dependent regulation of BDNF expression

✍ Scribed by Shieh, Perry B. ;Ghosh, Anirvan

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 137 KB
Volume: 41
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(199910)41:1<127::aid-neu16>3.0.co;2-j

No coin nor oath required. For personal study only.

✦ Synopsis

Activity-dependent changes in synaptic strength, which appear to underlie cortical plasticity, require long-lasting biochemical changes in the postsynaptic neuron. An inductive event common to several forms of synaptic plasticity is an influx of calcium into the postsynaptic cell. Calcium acts as a second messenger to set into motion a cascade of biochemical signaling events that leads to new gene expression. Brain-derived neurotrophic factor (BDNF) is one such calcium-regulated gene that appears to be involved in activity-dependent cortical plasticity. Studies of the mechanism by which calcium influx induces BDNF expression have revealed that the BDNF promoter is reg-ulated by two calcium response elements. One of the elements appears to be regulated by a novel transcription factor, while the other element is regulated by the previously characterized transcription factor CREB. The calcium signal is propagated to the CREB-mediated component of BDNF expression by CaM kinase IV. This signaling pathway, which links calcium influx to the induction of BDNF via CaM kinase IV and CREB, is likely to be centrally involved in mediating long-term activity-dependent plasticity.

📜 SIMILAR VOLUMES

Molecular mechanisms underlying dexameth

Molecular mechanisms underlying dexamethasone inhibition of iNOS expression and activity in C6 glioma cells

✍ Jun Shinoda; Katherine E. McLaughlin; Helen S. Bell; Gopal R. Swaroop; Shin-Ichi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 320 KB

The synthetic glucocorticoid dexamethasone is routinely used to stabilize patients with malignant gliomas. One putative target for glucocorticoid action is inducible nitric oxide synthase (iNOS), which is produced by the tumor cells as well as the host immune cells. In this study, we characterize th

Molecular mechanisms underlying lymphocy

Molecular mechanisms underlying lymphocyte recirculation II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells

✍ Takuya Tamatani; Masaharu Kotani; Toshiyuki Tanaka; Massayuki Miyasaka 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 425 KB

Molecular mechanisms of interleukin-4–in

Molecular mechanisms of interleukin-4–induced up-regulation of type I collagen gene expression in murine fibroblasts

✍ Tracy L. McGaha; Maithao Le; Takao Kodera; Cristina Stoica; Jinfang Zhu; William 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB 👁 1 views

## Abstract ## Objective There is evidence that interleukin‐4 (IL‐4) plays a major role in the induction of extracellular matrix protein synthesis in fibrotic disease. We therefore examined the effect of IL‐4 on collagen synthesis in primary fibroblasts isolated from normal and TSK/+ mice, which s

17β-Estradiol regulation of protein kina

17β-Estradiol regulation of protein kinase C activity in chondrocytes is sex-dependent and involves nongenomic mechanisms

✍ V. L. Sylvia; T. Hughes; D. D. Dean; B. D. Boyan; Z. Schwartz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB

17b-Estradiol (E 2 ) regulates growth plate chondrocyte differentiation in both a sex-and cell maturation-dependent manner, and the sex-specific effects of E 2 appear to be mediated in part by membrane events. In this study, we examined whether E 2 regulates protein kinase C (PKC) in a cell-maturati

Molecular mechanisms underlying IGF-I-in

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

✍ Yuhong Lu; Xiaolin Zi; Michael Pollak 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 450 KB

## Abstract The clinical usefulness of trastuzumab (Herceptin; Genentech, San Francisco, CA) in breast cancer treatment is limited by the rapid development of resistance. We previously reported that IGF‐I signaling confers resistance to the growth‐inhibitory actions of trastuzumab in a model system

Mechanical modulation of molecular signa

Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue

✍ Stefan Judex; Nan Zhong; Maria E. Squire; Kenny Ye; Leah-Rae Donahue; Michael Ha 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 262 KB

## Abstract Identifying the molecular mechanisms that regulate bone's adaptive response to alterations in load bearing may potentiate the discovery of interventions to curb osteoporosis. Adult female mice (BALB/cByJ) were subjected to catabolic (disuse) and anabolic (45 Hz, 0.3__g__ vibration for 1