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Activity-based fluorescent probes for monitoring sulfatase activity

✍ Scribed by Hyun-Joo Park; Hyun-Woo Rhee; Jong-In Hong

Book ID
116318670
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
418 KB
Volume
22
Category
Article
ISSN
0960-894X

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We have successfully designed and synthesized two fluorescently-labeled, activity-based probes, Probe 1 and Probe 2, which were shown to label protein tyrosine phosphatases specifically, as well as other types of phosphatases. The probes were not reactive towards the other non-phosphatase enzymes te