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Active stress kinase p38 enhances and perpetuates abnormal tau phosphorylation and deposition in Pick’s disease

✍ Scribed by Berta Puig; Francesc Vinals; Isidre Ferrer

Book ID: 106073029
Publisher: Springer-Verlag
Year: 2004
Tongue: English
Weight: 199 KB
Volume: 107
Category: Article
ISSN: 0001-6322
DOI: 10.1007/s00401-003-0793-z

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## Abstract Two of the earliest manifestations of the selective neurodegeneration that occurs in Alzheimer's disease (AD) involve the oxidative modification of various biomacromolecules and the reexpression of a multitude of cell cycle‐related proteins. Taken together with the proximal and ectopic