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Active site dynamics of the HhaI methyltransferase: insights from computer simulation

✍ Scribed by Edmond Y Lau; Thomas C Bruice


Book ID
115629647
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
302 KB
Volume
293
Category
Article
ISSN
0022-2836

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## Abstract The constitutive androstane receptor (CAR) possesses, unlike most other nuclear receptors, a pronounced basal activity __in vitro__ whose structural basis is still not fully understood. Using comparative molecular dynamics simulations of CAR X‐ray crystal structures, we evaluated the mo