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Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity

✍ Scribed by Eun-Joo Kim; Jeong-Hoon Kho; Moo-Rim Kang; Soo-Jong Um

Book ID
116754480
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
35 KB
Volume
28
Category
Article
ISSN
1097-2765

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## Abstract The tumor suppressor p53‐related p73 shares significant amino‐acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA‐binding sites and activates p53‐responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their