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Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway

✍ Scribed by Basant Kumar Thakur; Angelika Chandra; Tino Dittrich; Karl Welte; Prakash Chandra


Book ID
116303649
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
337 KB
Volume
424
Category
Article
ISSN
0006-291X

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## Abstract HIV‐1 Tat protein is an important pathogenic factor in HIV‐1‐associated neurological diseases. One hallmark of HIV‐1 infection of the central nervous system (CNS) is astrocytosis, which is characterized by elevated glial fibrillary acidic protein (GFAP) expression in astrocytes. We have