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Active demethylation of the paternal genome in the mouse zygote

โœ Scribed by J Oswald; S Engemann; N Lane; W Mayer; A Olek; R Fundele; W Dean; W Reik; J Walter


Book ID
114317622
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
240 KB
Volume
10
Category
Article
ISSN
0960-9822

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โœ Richard M. Schultz ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 1007 KB

Zygotic gene activation (ZGA) is the critical event that governs the transition from maternal to embryonic control of development. In the mouse, ZGA occurs during the 2-cell stage and appears to be regulated by the time following fertilization, i.e. a zygotic clock, rather than by progression throug