Mouse preimplantation embryos consume pyruvate preferentially during the early developmental stages, before glucose becomes the predominant energy substrate in the blastocyst. To investigate the importance of the switch to glucose utilization at the later developmental stages, mouse embryos from F1
Role of histone methylation in zygotic genome activation in the preimplantation mouse embryo
โ Scribed by Gen-Bao Shao; Hong-Mei Ding; Ai-Hua Gong
- Book ID
- 107427042
- Publisher
- Society for In Vitro Biology
- Year
- 2008
- Tongue
- English
- Weight
- 226 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1475-2689
No coin nor oath required. For personal study only.
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Zygotic gene activation (ZGA) is the critical event that governs the transition from maternal to embryonic control of development. In the mouse, ZGA occurs during the 2-cell stage and appears to be regulated by the time following fertilization, i.e. a zygotic clock, rather than by progression throug
A chromatin-based transcriptionally repressive state develops during the two-cell stage in preimplantation mouse embryos. Correlated with the initial formation of this state is the expression of somatic histone H1, which could confer repression by promoting the formation of a transcriptionally repre