Activation of thymic B cells by signals of CD40 molecules plus interleukin-10
โ Scribed by Muneo Inaba; Kayo Inaba; Yoh Fukuba; Shin-Ichiro Mori; Hiroki Haruna; Hiroshi Doi; Yasushi Adachi; Hiroshi Iwai; Naoki Hosaka; Hiroko Hisha; Hideo Yagita; Susumu Ikehara
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 599 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
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This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of
## Abstract Immunostimulatory CpG oligodeoxynucleotide (CpGโODN) sequences are known to directly activate Bโcells. We investigated the expression of the CpG receptor, Tollโlike receptorโ9 (TLR9), in humantonsil Bโcells, and determined functional responses following stimulation by a wellโcharacteriz