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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

✍ Scribed by Kip A West; S Sianna Castillo; Phillip A Dennis

Book ID
117764491
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
239 KB
Volume
5
Category
Article
ISSN
1368-7646

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of