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Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway

✍ Scribed by Roberta Bortul; Pier Luigi Tazzari; Anna Maria Billi; Giovanna Tabellini; Irina Mantovani; Alessandra Cappellini; Tiziana Grafone; Giovanni Martinelli; Roberto Conte; Alberto M. Martelli


Book ID
108673192
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
314 KB
Volume
129
Category
Article
ISSN
0007-1048

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of