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Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

✍ Scribed by Johan Bussink; Albert J van der Kogel; Johannes HAM Kaanders

Book ID
117784665
Publisher
The Lancet
Year
2008
Tongue
English
Weight
682 KB
Volume
9
Category
Article
ISSN
1470-2045

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## Abstract We investigated the status of the PI 3‐kinase/AKT/PTEN signaling pathway in a series of 117 head and neck squamous cell carcinomas (HNSCC) in a search for molecular alterations in genes/proteins with potential prognostic value. For this purpose, __PIK3CA__ and __AKT2__ gene amplificatio