Mouse skin tumors, benign papillomas, and squamous cell carcinomas (SCCs) were initiated by a single topical application of urethane followed by repeated promotion with 12-0-tetradecanoylphorbol-13-acetate (TPA). Using the NIH 3T3 focus forming assay, dominant transforming activity was detected in D
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
✍ Scribed by Balmain, Allan; Ramsden, Martin; Bowden, George T.; Smith, John
- Book ID
- 109734514
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 428 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/307658a0
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## Abstract Both papillomas and squamous cell carcinomas (SCC) induced in mouse epidermis by initiation with 7,12‐dimethylbenz[__a__]anthracene (DMBA) and promotion with 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA) exhibit aberrant expression of a type I keratin, K13, that is normally characteris
## Abstract As part of an evaluation of the effectiveness of using __ras__ mutation analysis for distinguishing carcinogen‐induced from spontaneous tumors, we examined the profile of __ras__ gene point mutations in spontaneous, 7,12‐dimethylbenz[__a__]anthracene (DMBA)‐induced, and N‐nitrosodiethyl