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Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

✍ Scribed by Goodridge, Helen S.; Reyes, Christopher N.; Becker, Courtney A.; Katsumoto, Tamiko R.; Ma, Jun; Wolf, Andrea J.; Bose, Nandita; Chan, Anissa S. H.; Magee, Andrew S.; Danielson, Michael E.


Book ID
109900549
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
662 KB
Volume
472
Category
Article
ISSN
0028-0836

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## Abstract Formation of immune synapses (IS) between T cells and APC requires multiple rearrangements in the actin cytoskeleton and selective receptor accumulation in supramolecular activation clusters (SMAC). The inner cluster (central SMAC) contains the TCR/CD3 complex. The outer cluster (periph