Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

FMRFamide-like peptides encoded on the f

FMRFamide-like peptides encoded on the flp-18 precursor gene activate two isoforms of the orphan Caenorhabditis elegans G-protein-coupled receptor Y58G8A.4 heterologously expressed in mammalian cells

✍ Teresa M. Kubiak; Martha J. Larsen; Jerry W. Bowman; Timothy G. Geary; David E. 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 419 KB 👁 2 views

## Abstract Two alternatively spliced variants of an orphan __Caenorhabditis elegans__ G‐protein‐coupled receptors (GPCRs; Y58G8A.4a and Y58G8A.4b) were cloned and functionally expressed in Chinese hamster ovary (CHO) cells. The Y58G8A.4a and Y58G8A.4b proteins (397 and 433 amino acid residues, res