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Activation of the Human p27Kip1 Promoter by IFNα 2b

✍ Scribed by Alejandro Moro; Alicia Santos; Manuel J. Araña; Silvio E. Perea

Book ID
115585348
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
88 KB
Volume
269
Category
Article
ISSN
0006-291X

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Our previous study demonstrate that vitamin D 3 induces the binding of vitamin D 3 receptor (VDR) to Sp1 transcription factor and stimulates p27 Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as