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MODULATION OF THE p27KIP1 CYCLIN-DEPENDENT KINASE INHIBITOR EXPRESSION DURING IL-4-MEDIATED HUMAN B CELL ACTIVATION

✍ Scribed by BLANCHARD, Dominique Alain; AUFFREDOU, Marie Thérèse; VAZQUEZ, Aimé


Book ID
122221399
Publisher
Portland Press
Year
1996
Tongue
English
Weight
184 KB
Volume
88
Category
Article
ISSN
0248-4900

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The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder