## Abstract Cyclin D1 is a wellβknown cell cycle regulator. Recently, its proβsurvival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated
Activation of STAT5-cyclin D1 Pathway in Chewing Tobacco Mediated Oral Squamous Cell Carcinoma
β Scribed by Rajakishore Mishra; Bibhu Ranjan Das
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 338 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0301-4851
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## Abstract Cyclin E and Cdk2 have been shown to play an important role in G1/S transition of the cell cycle. Two Eβtype cyclins (E1 and E2) have been identified to date and share functionally similarities. Upregulation of these cyclins has been observed frequently in human cancers. We examined the
## Abstract ## BACKGROUND Cyclin D1 (__CCND1__) and __p16__ alterations have been detected in oral squamous cell carcinomas (SCCs), suggesting that abnormalities of these genes may play an important role in the genesis or progression of oral SCCs and serve as independent prognostic indicators. The