BACKGROUND. The laminin-5 ␥2 chain plays an important role in cell migration during tumor invasion and tissue remodeling. METHODS. Laminin-5 ␥2 chain expression in squamous cell carcinomas of the tongue in 67 patients with Stage II, III, or IVA,B (excluding the cases with distant metastasis) was exa
✦ LIBER ✦
Analysis of activated EGFR signalling pathways and their relation to laminin-5 γ2 chain expression in oral squamous cell carcinoma (OSCC)
✍ Scribed by Petra Richter; Frank D. Böhmer; Winfried Hindermann; Laura Borsi; Peter Hyckel; Peter Schleier; Detlef Katenkamp; Hartwig Kosmehl; Alexander Berndt
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 777 KB
- Volume
- 124
- Category
- Article
- ISSN
- 1432-119X
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## Abstract Cancer cell invasion is facilitated by extracellular matrix degrading proteases such as plasmin. We have studied the expression of plasminogen activator inhibitor‐1 (PAI‐1) and urokinase receptor (uPAR) together with the γ2‐chain of laminin‐5 (lam‐γ2) by immunohistochemistry in 20 cases