## Abstract Collagenase‐3 (MMP‐13) is characterized by an exceptionally wide substrate specificity and restricted expression. MMP‐13 is 1 of the few MMPs primarily expressed by tumor cells in malignant tumors, __e.g.__, squamous cell carcinomas and its expression correlates with their invasion capa
✦ LIBER ✦
Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells
✍ Scribed by Leivonen, S-K; Ala-aho, R; Koli, K; Grénman, R; Peltonen, J; Kähäri, V-M
- Book ID
- 110070314
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 535 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
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## Background: Serine proteases have important roles in tumor invasion and metastasis, and their inhibitors, serine protease inhibitors (serpins), are attractive targets for therapeutic strategies. on chromosome 18q21, there is a cluster of serpins: maspin, headpin, and squamous cell carcinoma anti
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