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Activation of PPAR prevents endothelial dysfunction induced by overexpression of amyloid- precursor protein

โœ Scribed by d'Uscio, L. V.; Das, P.; Santhanam, A. V. R.; He, T.; Younkin, S. G.; Katusic, Z. S.


Book ID
118277037
Publisher
Oxford University Press
Year
2012
Tongue
English
Weight
483 KB
Volume
96
Category
Article
ISSN
0008-6363

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Endothelial cell dysfunction in response
โœ Nadia Jahroudi; Jana Kitney; Joel S. Greenberger; Robert Bowser ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 928 KB

Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (Aโค) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic