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Activation of peripheral blood lymphocytes in patients with primary sjögren's syndrome

✍ Scribed by P. Youinou; Y. L. Pennec; M. A. Blaschek; A. Gentric; J. Jouquan; A. Lamour; P. Angelidis

Publisher
Springer
Year
1988
Tongue
English
Weight
534 KB
Volume
8
Category
Article
ISSN
0172-8172

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✦ Synopsis

The peripheral blood from 15 patients with primary Sjögren's syndrome and from 15 matched controls was examined for the presence of activated T and B lymphocytes, by using monoclonal antibodies directed to interleukin-2 (IL-2) and transferrin receptors, and to HLA-DR determinants. The number of circulating positive-T cells was significantly greater in the patients than in the controls, irrespective of disease activity. There were more of the CD8 cells than of the CD4 cells that expressed IL-2 receptors. There was a small but significant increase in activated B cells in the patients, since this population is virtually absent from the normal blood.

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