Activation of p44/p42 Mitogen-Activated Protein Kinase Limits Triiodothyronine-Stimulated Alkaline Phosphatase Activity in Osteoblasts
โ Scribed by Osamu Kozawa; Daijiro Hatakeyama; Minoru Yoshida; Yasuka Kamiya; Chihiro Kondo; Hiroyuki Matsuno; Toshihiko Uematsu
- Book ID
- 115588571
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 78 KB
- Volume
- 286
- Category
- Article
- ISSN
- 0006-291X
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We previously reported that prostaglandin F 2โฃ (PGF 2โฃ ) activates both phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells and then induces the activation of protein kinase C (PKC). In this study, we investigated the eff