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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

✍ Scribed by Osborne, Barbara A.; Gottipati, Sridevi; Aster, Jon C.; Hahn, William C.; Weijzen, Sanne; Rizzo, Paola; Braid, Mike; Vaishnav, Radhika; Jonkheer, Suzanne M.; Zlobin, Andrei


Book ID
109933188
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
864 KB
Volume
8
Category
Article
ISSN
1078-8956

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Somatic cell hybrids were isolated from fusions of diploid embryonic rat fibroblasts with transformed Rat-1 cells which contained 4 to 5 copies of the transforming human Ha-ras 1 gene. In contrast to their transformed parental cells four hybrid clones showed normal morphology, long latency periods o