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Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors

✍ Scribed by Stonecypher, Mark S; Byer, Stephanie J; Grizzle, William E; Carroll, Steven L


Book ID
110069776
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
620 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract Neuregulin‐1 (NRG‐1) proteins promote Schwann cell survival, differentiation and proliferation during development. High levels of an NRG‐like activity are also present in some human peripheral nerve sheath tumors, suggesting that NRG‐1 isoforms may be involved in the development of thes