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Activation of nitric oxide pathway mediated by metabotropic glutamate receptors in primary cultures of cerebellar granule cells

✍ Scribed by N. V. Gorbunov

Publisher
Springer US
Year
1995
Tongue
English
Weight
406 KB
Volume
120
Category
Article
ISSN
0007-4888

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Ca2+ entry induced by N-methyl-D-aspartate (NMDA) in neurons and by noradrenaline (NA) in astrocytes is known to increase intracellular cyclic GMP (cGMP) levels through stimulation of the Ca2+-dependent nitric oxide synthase type I (NOS-I). The possibility that Ca2+ entry could also down-regulate in