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Activation of nicotinic α7 acetylcholine receptor enhances long term potentation in wild type mice but not in APPswe/PS1ΔE9 mice

✍ Scribed by Andreas Söderman; Jens D. Mikkelsen; Mark J. West; Ditte Z. Christensen; Morten S. Jensen

Book ID: 116772736
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 246 KB
Volume: 487
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2010.10.049

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## Abstract Both impaired nicotinic neurotransmission and the inheritance of apoE4 are associated with increased risk for Alzheimer disease (AD) as well as other deficiencies in memory‐related behavior. Long‐term potentiation (LTP), a cellular model of memory, is known to be altered by nicotinic ag