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Activation of nicotinic alpha 7 acetylcholine receptor enhances long-term potentiation in wild-type mice, but not APPswe/PS1deltaE9 mice

✍ Scribed by West, Mark; Söderman, Andreas; Mikkelsen, Jens D.; Christensen, Ditte; Jensen, Morten S.


Book ID
122769946
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
45 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract Both impaired nicotinic neurotransmission and the inheritance of apoE4 are associated with increased risk for Alzheimer disease (AD) as well as other deficiencies in memory‐related behavior. Long‐term potentiation (LTP), a cellular model of memory, is known to be altered by nicotinic ag