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Activation of NF-κB signalling and TNFα-expression in THP-1 macrophages by TiAlV- and polyethylene-wear particles

✍ Scribed by Bernd Baumann; Jochen Seufert; Franz Jakob; Ulrich Nöth; Olaf Rolf; Jochen Eulert; Christof P. Rader


Book ID
113834651
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
203 KB
Volume
23
Category
Article
ISSN
0736-0266

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## Abstract Bone loss that causes aseptic loosening of orthopedic implants is initiated by pro‐inflammatory cytokines produced by macrophages in response to implant‐derived wear particles. MAPK and NF‐κB signaling pathways are activated by the particles; however, it is not clear which of the signal